The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2000
Filed:
May. 21, 1999
Applicant:
Inventors:
Vivekananda M Vrudhula, Killingworth, CT (US);
Gene M Dubowchik, Middlefield, CT (US);
Bireshwar Dasgupta, Middletown, CT (US);
Dolatrai M Vyas, Madison, CT (US);
Assignee:
Bristol-Myers Squibb Company, Princeton, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
514318 ; 560 41 ; 562459 ; 562463 ; 562568 ; 564209 ; 514354 ; 514449 ; 514538 ; 514549 ; 514550 ; 546226 ; 546194 ; 5462791 ; 548533 ;
Abstract
The present invention relates to the design, synthesis, and the peptidyl-prolyl isomerase (PPIase or rotamase) inhibitory activity of novel .alpha.,.alpha.-difluoroacetamido compounds that are neurotrophic agents (i.e. compounds capable of stimulating growth or proliferation of nervous tissue) and that bind to immunophilins such as FKBP12 and inhibit their rotamase activity. This invention also relates to pharmaceutical compositions comprising these compounds.