The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2000
Filed:
Oct. 26, 1998
Applicant:
Inventors:
Joye L Bramble, Lansdale, PA (US);
Fernando J Muzzio, Spotswood, NJ (US);
James A Searles, Boulder, CO (US);
Assignees:
Merck & Co., Inc., Rahway, NJ (US);
Rutgers, The State University of New Jersey, New Brunswick, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12M / ;
U.S. Cl.
CPC ...
435394 ; 435395 ; 4352867 ; 4353033 ; 4353041 ; 366219 ;
Abstract
A method for enhancing the mixing of materials in a roller bottle by the introduction of controlled axial and cross-sectional flow perturbations is disclosed. The effectiveness of the method is demonstrated by achieving higher efficiency in cell culturing and virus propagation in roller bottles by introducing controlled flow perturbations during the process.