The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 2000
Filed:
Nov. 25, 1998
Applicant:
Inventors:
Mehran Yazdanian, Danbury, CT (US);
Barbara J Bormann, Southington, CT (US);
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT (US);
Primary Examiner:
Int. Cl.
CPC ...
C12Q / ; C12Q / ; C07H / ; C12P / ; C12N / ;
U.S. Cl.
CPC ...
435 4051 ; 536 2372 ; 435-6 ; 435 691 ; 435325 ;
Abstract
A brain microvessel endothelial cell having a Middle-T antigen gene from papovirus is disclosed. The brain microvessel endothelial cell exhibits normal cell phenotype, maintains the phenotype in culture and forms monolayers substantially impermeable to low molecular weight molecules. The cells are useful for in vitro studies involving the blood brain barrier. Also disclosed, are methods of using and processes of making these cells.