The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 25, 2000

Filed:

May. 16, 1998
Applicant:
Inventors:

Paul W Wedeking, Pennington, NJ (US);

Ruth E Wager, Rockville, MD (US);

Thangavel Arunachalam, Plainsboro, NJ (US);

Kondareddiar Ramalingam, Dayton, NJ (US);

Karen E Linder, Kingston, NJ (US);

Ramachandran S Ranganathan, Princeton, NJ (US);

Adrian D Nunn, Lambertville, NJ (US);

Natarajan Raju, Kendall Park, NJ (US);

Michael F Tweedle, Princeton, NJ (US);

Assignee:

Bracco Research USA Inc., Princeton, NJ (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; A61M / ;
U.S. Cl.
CPC ...
424-165 ; 424-91 ; 424-111 ; 424-169 ; 534 10 ; 534 14 ;
Abstract

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the .alpha., .gamma., or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.


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