The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2000
Filed:
Jun. 25, 1999
Applicant:
Inventors:
Roger P Bakale, Shrewsbury, MA (US);
Jorge L Lopez, San Juan, PR (US);
Francis X McConville, Grafton, MA (US);
Charles P Vandenbossche, Marlborough, MA (US);
Chris Hugh Senanayake, Shrewsbury, MA (US);
Assignee:
Sepracor Inc., Marlborough, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; C07B / ;
U.S. Cl.
CPC ...
560 40 ; 562402 ; 562468 ;
Abstract
A process for the preparation of optically active phenylcyclohexylglycolate esters is described. The process utilizes carboxylic acid activation to couple (R)-- or (S)-cyclohexylphenylglycolic acid (CHPGA) with 4-N,N-diethylamino butynol or other propargyl alcohol derivatives. The preparation of the hydrochloride salt is also described. In addition, a resolution process employing tyrosine methyl ester enantiomers for preparing a single enantiomer of CHPGA from racemic CHPGA is disclosed.