The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2000
Filed:
Dec. 22, 1997
Applicant:
Inventors:
Assignee:
Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C12N / ; A61K / ; G01N / ;
U.S. Cl.
CPC ...
435-721 ; 530350 ; 530413 ; 514-2 ; 435-71 ; 435 691 ;
Abstract
The receptor for interleukin-18 (IL-18) is described. The invention provides recombinant receptor polypeptides, including soluble receptors and fusion proteins, which specifically bind to IL-18 and inhibit its activity. The polypeptides are thus useful as pharmaceutical agents to treat autoimmune and allergic diseases. They are also useful as affinity reagents to purify IL-18, in assays to detect the ligand, and in screening assays to identify IL-18 agonists or antagonists.