The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2000
Filed:
Oct. 28, 1997
Applicant:
Inventors:
Steven M Friedman, Tenafly, NJ (US);
Mary K Crow, New York, NY (US);
Yixin Li, New York, NY (US);
Joseph R Tumang, Woodhaven, NY (US);
Guang-Rong Sun, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C07K / ;
U.S. Cl.
CPC ...
536 235 ; 536 231 ; 530324 ; 530326 ; 530330 ;
Abstract
Four unique transcripts have been isolated from the .beta. chain of the T cell receptor in T cells in the synovial tissue of a patient with rheumatoid arthritis. Two of these transcripts were isolated from fresh synovial tissue and two were isolated from a T cell line derived from the synovial tissue. The sequences of the four transcripts are highly homologous, with a conserved amino acid sequence of IGQ.sub.-- N in the highly diverse V-D junction. The .alpha. chain and the antigenic specificity of the T cell line derived transcripts has also been characterized.