The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2000
Filed:
Sep. 25, 1998
John E Hengeveld, Kenosha, WI (US);
Elise H Leese, Libertyville, IL (US);
Brian S Moon, Holland, MI (US);
Dennis M Abad, Wheeling, IL (US);
Kimberly A Allen, Silver Lake, WI (US);
Philip E Bauer, Grayslake, IL (US);
David B Murphey, Gurnee, IL (US);
Brian T Fohey, Kenosha, WI (US);
Richard R Copp, Jr, Kenosha, WI (US);
Greg S Lannoye, Wildwood, IL (US);
Rodney M Mittag, Chicago, IL (US);
Abbott Laboratories, Abbott Park, IL (US);
Abstract
The present invention provides a simple, 1-step process for preparing a N-(aryl or heteroaryl)-hydroxyurea comprising reacting the corresponding alcohol, ester or ether with hydroxyurea and acid. This reaction is particularly useful for preparing a benzo[b]thienyl substituted N-hydroxyurea of formula: ##STR1## from compound 1: ##STR2## by reacting compound 1 with hydroxyurea and acid. R.sup.1 is selected from the group consisting of hydrogen, 1-6 carbon alkyl, 1-6 carbon alkoxy, and halogen; R.sup.2 is an 1-4 carbon alkyl; and R.sup.3 is selected from the group consisting of hydrogen, acyl, methyl, ethyl and mixtures thereof. Additional steps to isolate the pure bulk product follow.