The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2000
Filed:
Jan. 23, 1998
Applicant:
Inventors:
Linda G Lee, Palo Alto, CA (US);
Ronald J Graham, Pleasanton, CA (US);
Khairuzzaman B Mullah, Union City, CA (US);
Francis T Haxo, San Francisco, CA (US);
Assignee:
The Perkin-Elmer Corporation, Foster City, CA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
548100 ; 435-6 ; 536 221 ; 536 253 ; 548120 ; 548146 ; 548148 ; 548181 ; 548215 ; 548217 ; 548223 ;
Abstract
The invention provides an asymmetric cyanine dye compound having the structure ##STR1## including substituted forms thereof, wherein, at least one of R.sub.1 and R.sub.2 is linking group, X is O, S, or Se, and n ranges from 0 to 2. The invention further provides reporter-quencher dye pairs comprising the asymmetric cyanine dyes, dye-labeled polynucleotides incorporating the asymmetric cyanine dyes, and hybridization detection methods utilizing the dye-labeled polynucleotides.