The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2000
Filed:
Apr. 30, 1998
Tadakatsu Mandai, Okayama, JP;
Hiroshi Okumoto, Okayama-ken, JP;
Katsuyoshi Nakanishi, Yokohama, JP;
Koji Hara, Yokohama, JP;
Katsuhiko Mikuni, Yokoyama, JP;
Kozo Hara, Yokohama, JP;
Teruhiko Umetsu, Tokyo, JP;
Bio Research Corporation of Yokohama, Yokohama, JP;
Ensuiko Sugar Refining Co., Ltd., Yokohama, JP;
Kaken Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
Disclosed are ursodeoxycholic acid derivatives having an increased solubility in water, and methods for producing the derivatives. To produce the derivatives, ursodeoxycholic acid is protected at its carboxyl group with a benzyl group, then reacted with tetrabenzyl-acetic acid-oxyglucoside of the following formula (1), and de-benzylated; or ursodeoxycholic acid is protected at its hydroxyl group with a t-butyldimethylsilyl group, then reacted with tetrabenzyl-2-hydroxyethyloxyglucoside of the following formula (2), and de-t-butyldimethylsilylated and de-benzylated. ##STR1##