The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2000
Filed:
Oct. 09, 1997
Applicant:
Inventors:
Olavi Siiman, Davie, FL (US);
Alexander Burshteyn, Hialeah, FL (US);
John A Maples, Miami Shores, FL (US);
James Keller Whitesell, Austin, TX (US);
Assignee:
Coulter International Corp., Miami, FL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N / ;
U.S. Cl.
CPC ...
436518 ; 427-211 ; 427-213 ; 427-214 ; 427131 ; 42721335 ; 427215 ; 427216 ; 427337 ; 427338 ; 428403 ; 428407 ; 435-5 ; 435-721 ; 436524 ; 436525 ; 436526 ; 436529 ; 436531 ; 436532 ; 436533 ; 436534 ;
Abstract
A stable protein-coated nickel particle useful in biological assays contains a nickel particle having removed from the surface thereof nickel oxide; a linker attached to said nickel particle, the linker having a free amino group; and a protein attached to said linker by covalently bonding to the free amino group. Methods of producing and using these oxide-free nickel-protein conjugates are disclosed.