The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2000

Filed:

Jan. 28, 1999
Applicant:
Inventors:

Nambi V Aiyar, Berwyn, PA (US);

Jyoti Disa, King of Prussia, PA (US);

Assignee:

SmithKline Beecham Corporation, Philadelphia, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ; C07K / ;
U.S. Cl.
CPC ...
435 691 ; 435 711 ; 435 712 ; 4352523 ; 43525411 ; 4353201 ; 435325 ; 435471 ; 536 231 ; 536 235 ; 536 243 ; 536 2431 ; 536 245 ; 530350 ;
Abstract

BECRLR polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing BECRLR polypeptides and polynucleotides in screening assays to discover compounds that either agonize or antagonize the biological activity of the receptor. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.


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