The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2000
Filed:
Aug. 26, 1998
Applicant:
Inventors:
Michael W Reed, Seattle, WA (US);
Igor V Kutyavin, Bothell, WA (US);
Eugeny A Lukhtanov, Bothell, WA (US);
J Ansel Wald, Seattle, WA (US);
Rich B Meyer, Jr, Woodinville, WA (US);
Assignee:
Epoch Pharmaceuticals, Inc., Redmond, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ; C07H / ; C12Q / ; A01N / ;
U.S. Cl.
CPC ...
536 231 ; 435-6 ; 514-1 ; 514 44 ; 536 221 ; 536 253 ; 536 2532 ; 536 266 ;
Abstract
Diaziridinyl-aryl and bis-[di(chloroethyl)amino]-aryl oligonucleotide conjugates have a sequence that is complementary in the triplex forming sense to a target sequence in duplex nucleic acid. The diaziridinyl-aryl and bis-[di(chloroethyl)amino]-aryl oligonucleotide conjugates effectively cross-link with both strands of the targeted duplex nucleic acid.