The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2000
Filed:
Dec. 17, 1996
Applicant:
Inventors:
Mark Rolfe, Newton Upper Falls, MA (US);
Maria Isabel Chiu, Boston, MA (US);
Guillaume Cottarel, West Roxbury, MA (US);
Vivian Berlin, Dunstable, MA (US);
Veronique Damagnez, Cambridge, MA (US);
Giulio Draetta, Winchester, MA (US);
Assignee:
Mitotix, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N / ;
U.S. Cl.
CPC ...
435-721 ; 435 29 ; 435-4 ; 435-6 ; 435-71 ; 435 23 ; 435 691 ; 435-72 ; 435193 ; 530350 ;
Abstract
The present invention relates to drug screening assays which provide a systematic and practical approach for the identification of candidate agents able to inhibit ubiquitin-mediated degradation of a cell-cycle regulatory protein, such as p53, p27, myc, fos, MAT.alpha.2, or cyclins. The invention further relates to novel ubiquitin-conjugating enzymes, and uses related thereto.