The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2000
Filed:
Jul. 29, 1997
Applicant:
Inventors:
Kouji Matsushima, Ishikawa, JP;
Yoshihiro Matsumoto, Shizuoka, JP;
Yoshiki Yamada, Shizuoka, JP;
Koh Sato, Shizuoka, JP;
Masayuki Tsuchiya, Shizuoka, JP;
Tatsumi Yamazaki, Shizuoka, JP;
Assignee:
Chugai Pharmaceutical Co., Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ;
U.S. Cl.
CPC ...
4241451 ; 4241301 ; 4241331 ; 4241391 ; 4241411 ; 4241521 ; 4241581 ; 5303871 ; 5303873 ; 5303879 ; 5303881 ; 5303882 ; 53038823 ;
Abstract
Monoclonal antibodies immunospecific for the neutrophil chemotactic factor, IL-8, have been humanized by reshaping the variable regions to conform more closely to human counterparts. These antibodies are useful in immunoassays to detect IL-8 and as ligands on immunoaffinity columns for purification of human IL-8. In addition, the humanized antibodies have an antiinflammatory effect in patients.