The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2000
Filed:
Jun. 29, 1998
Applicant:
Inventors:
Karel M Brands, Jersey City, NJ (US);
John M Williams, Belle Mead, NJ (US);
Ulf H Dolling, Westfield, NJ (US);
Ronald B Jobson, East Brunswick, NJ (US);
Antony J Davies, Hertford Heath, GB;
Ian F Cottrell, Hertford, GB;
Mark Cameron, Bishops Stortford, GB;
Michael S Ashwood, Bishops Stortford, GB;
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07F / ;
U.S. Cl.
CPC ...
548111 ; 548453 ; 548412 ; 548413 ; 548533 ; 548536 ;
Abstract
A process of synthesizing a compound of the formula 1: ##STR1## is described. A compound of the formula 2: ##STR2## is reacted with diphenylphosphinic chloride to activate the carboxylic acid group, and then reacted with methanesulfonyl chloride to produce a compound of formula 4: ##STR3## Compound 4 is then reacted with a group II metal sulfide source in water to produce a compound of formula 1.