The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2000
Filed:
Nov. 20, 1997
Adel M Moussa, Burlington, MA (US);
Richard J Lombardy, Waltham, MA (US);
Reem M Haider, Malden, MA (US);
Minghua Sun, Libertyville, IL (US);
Pharm-Eco Laboratories, Inc., Lexington, MA (US);
Abstract
Disclosed is a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by the following structural formula: ##STR1## and a starting material represented by the following structural formula: ##STR2## Phenyl Ring A, Phenyl Ring B and Phenyl Ring C are independently unsubstituted or substituted with one, two or three substituents. Each substituent on Phenyl Ring A, Phenyl Ring B and Phenyl Ring C is independently chosen. R is --H, a aliphatic group, a substituted aliphatic group, an aryl group, a substituted aryl group, --C(O)--R', --C(O)--H, --C(O)--NHR', --S(O).sub.2 R', --C(O)--C(O)--R', --C(O)--C(O)--H, --C(S)--R', --C(S)--H, --C(O)--OR', --C(S)--OR', --C(O)--SR', --C(S)--SR', --C(O)--NR'.sub.2 or --C(O)--C(S)--R'. R' is an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R.sub.1 is a leaving group. The present invention also includes novel compounds which are intermediates in the preparation of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines.