The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 16, 2000
Filed:
Dec. 10, 1998
Applicant:
Inventors:
Jose Luis Pineiro, Bishops Stortford, GB;
Raymond George Hill, Royston, GB;
Assignee:
Merck Sharp & Dohme Ltd., Hoddesdon, GB;
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
514248 ; 5142265 ; 514406 ; 514473 ;
Abstract
A class of substituted 7,8-ring fused 1,2,4-triazolo[4,3-b]pyridazine derivatives as shown in Formula I, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 3-position and a substituted alkoxy moiety at the 6-position, are selective ligands for GABA.sub.A receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of pain. ##STR1##