The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2000
Filed:
Jun. 23, 1997
John Dimaio, Montreal, CA;
M Arshad Siddiqui, Saint-Laurent, CA;
John W Gillard, Baie d'Urfe, CA;
Yves St-Denis, Montreal, CA;
Micheline Tarazi, Montreal, CA;
Patrice Preville, Saint-Charles Borromee, CA;
Sophie Levesque, Laval, CA;
Benoit Bachand, Montreal, CA;
Annette Marian Doherty, Paris, FR;
Jeremy John Edmunds, Ypsilanti, MI (US);
Biochem Pharma Inc., Laval, CA;
Abstract
This invention relates to the discovery of heterocyclic competitive inhibitors of the enzyme thrombin, their preparation, and pharmaceutical compositions thereof. As well, this invention relates to the use of such compounds and compositions in vitro as anticoagulants and in vivo as agents for the treatment and prophylaxis of thrombotic disorders such as venous thrombosis, pulmonary embolism and arterial thrombosis resulting in acute ischemic events such as myocardial infarction or cerebral infarction. Moreover, these compounds and compositions have therapeutic utility for the prevention and treatment of coagulopathies associated with coronary bypass operations as well as restenotic events following transluminal angioplasty.