The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 25, 2000
Filed:
May. 05, 1999
Applicant:
Inventors:
Martha Jean Kelly, Norristown, PA (US);
Damian Gerard Weaver, Lansdale, PA (US);
Assignee:
Rohm and Haas Company, Phila., PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F / ; C07F / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
546 14 ; 546-4 ; 546294 ; 546296 ; 546298 ; 546301 ; 546302 ; 546303 ; 546314 ; 546348 ;
Abstract
This invention relates to a process for preparing 2-substituted pyridines via metal halogen exchange with sec-butyllithium on optionally substituted 2-bromo or 2-iodopyridines. The resulting lithopyridine intermediate is reacted with an electrophile to provide the desired 2-substituted pyridine. The substitution of sec-butyllithium for n-butyllithium in such a process results in an enhanced yield and purity of the desired 2-substituted pyridine.