The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2000
Filed:
Feb. 19, 1998
Applicant:
Inventors:
Alejandro A Aruffo, Belle Mead, NJ (US);
Diane Hollenbaugh, Newtown, PA (US);
Anthony W Siadak, Seattle, WA (US);
Karen K Berry, Princeton, NJ (US);
Linda Harris, Seattle, WA (US);
Barbara A Thorne, Issaquah, WA (US);
Jurgen Bajorath, Lynnwood, WA (US);
Assignee:
Bristol-Myers Squibb Co., New York, NY (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07K / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
4241441 ; 4241301 ; 4241331 ; 4241411 ; 4241431 ; 4241531 ; 4241731 ; 4352523 ; 4353201 ; 435452 ; 5303871 ; 5303873 ; 5303882 ; 53038822 ; 5303887 ; 53038873 ; 536 2353 ;
Abstract
The Applicants have discovered a novel antibody, more specifically a chimerized anti-human CD40 monoclonal antibody, which blocks the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent antigens, collagen induced arthritis, and skin transplantation, and are also useful for their anti-inflammatory properties.