The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2000
Filed:
Feb. 13, 1997
Applicant:
Inventors:
Wolfgang Pfleiderer, Konstanz, DE;
Frank Bergmann, Weissenberg, DE;
Assignee:
Hoechst Aktiengesellschaft, Frankfurt am Main, DE;
Primary Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ; C07H / ;
U.S. Cl.
CPC ...
536 253 ; 536 2531 ; 536 2532 ; 536 254 ; 536 267 ; 536 2671 ; 536 2672 ; 536 2674 ; 536 278 ;
Abstract
A process for the chemical synthesis of oligonucleotides Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quantities.