The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2000
Filed:
Dec. 15, 1998
Ben C Askew, Lansdale, PA (US);
Paul J Coleman, Wallingford, PA (US);
Mark E Duggan, Schwenksville, PA (US);
Wasyl Halczenko, Lansdale, PA (US);
George D Hartman, Lansdale, PA (US);
Cecilia A Hunt, Plymouth Meeting, PA (US);
John H Hutchinson, Philadelphia, PA (US);
Robert S Meissner, Schwenksville, PA (US);
Michael A Patane, Harleysville, PA (US);
Garry R Smith, Limerick, PA (US);
Jiabing Wang, Lansdale, PA (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors .alpha.v.beta.3, .alpha.v.beta.5, and/or .alpha.v.beta.6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.