The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 04, 2000
Filed:
Jul. 23, 1999
M Alexandra Glucksmann, Somerville, MA (US);
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The invention provides nucleic acids encoding a TRBP polypeptide, fragments thereof and homologs thereof The invention also provides TRBP polypeptides, fragments thereof and homologs thereof, and TRBP binding proteins. Methods for treating diseases or conditions characterized by an aberrant TRBP activity, e.g., by administering to the subject a TRBP therapeutic, are also disclosed. Diseases or conditions that can be treated according to the methods of the invention include thyroid-related disorders, metabolic disorders, and diabetes. Also disclosed are methods for predicting whether a subject is at risk of developing a disease associated with an aberrant TRBP activity, by determining, e.g., whether the subject has a genetic lesion in a TRBP gene and assays for identifying TRBP therapeutics.