The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 28, 2000
Filed:
Aug. 04, 1998
Applicant:
Inventors:
Uko Effiong Udodong, Indianapolis, IN (US);
John Leo Grutsch, Jr, Indianapolis, IN (US);
Marvin Martin Hansen, Indianapolis, IN (US);
Allen Robert Harkness, Indianapolis, IN (US);
Daniel Edward Verral, II, Clinton, IN (US);
Assignee:
Eli Lilly & Co., Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07F / ; C07K / ;
U.S. Cl.
CPC ...
530317 ; 514-7 ; 530345 ; 558152 ;
Abstract
The present invention provides phosphonylating agents and phosphonylation conditions that are compatible with the acid- and base-sensitive compounds and which promote a regioselective and reproducible conversion to a phosphonate compound. Also provided are intermediates that may be used to prepare phosphonate derivatives of cyclic peptides antifungal agent and a process for converting the phosphonates to the desired phosphonic acid prodrugs.