The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2000
Filed:
Jul. 31, 1998
Charles A Dvorak, Palo Alto, CA (US);
Douglas L Wren, Palo Alto, CA (US);
Lawrence E Fisher, Mountain View, CA (US);
Steven D Axt, San Jose, CA (US);
Eric R Humphreys, San Bruno, CA (US);
Humberto B Arzeno, Cupertino, CA (US);
Colin C Beard, Palo Alto, CA (US);
Sam Linh Nguyen, Denver, CO (US);
Yeun-Kwei Han, Louisville, CO (US);
Christopher R Roberts, Berthoud, CO (US);
Jan P Lund, Boulder, CO (US);
Paul R Fatheree, San Francisco, CA (US);
Syntex (U.S.A.) Inc., Palo Alto, CA (US);
Abstract
Process and novel intermediates for preparing the L-mono-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts. The present process and intermediates provide for reduced impurities in the mono-valine ester end-product and lower overall production costs. The process involves the condensation of a silylated guanine compound with a substituted glycerol derivative and esterification of this product with an L-valine derivative. These mono-valine products are of value as antiviral agents with improved absorption.