The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 21, 2000
Filed:
Dec. 24, 1997
Nigishi Hotta, Aichi, JP;
Hiroki Fujisawa, Hyogo, JP;
Nippon Zoki Pharmaceuticals Co., Ltd., Osaka, JP;
Abstract
The production of 3-deoxyglucosone, which is an intermediate in the Maillard reaction and induces a crosslinking glycation of proteins participating in various diseases, is inhibited with an inhibitor containing at least one parabanic acid derivative as an effective ingredient. The at least one parabanic acid derivative is represented by the following formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein, R is hydrogen or lower alkyl; X is hydrogen, alkyl, cycloalkyl, lower alkylcycloalkyl, phenyl or phenylalkyl which is optionally substituted with lower alkyl, lower alkoxy, nitro and/or halogen; and n is an integer of from 1 to 4. Inhibiting the production of 3-DG, which is a highly active intermediate which participates in the formation of crosslinked protein in the Maillard reaction is useful for the treatment and the prevention of various diseases induced by deposition into tissues or sclerosis or denaturation of crosslinked protein, or diseases induced by aging and diabetic complications.