The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2000
Filed:
May. 23, 1997
Applicant:
Inventors:
Eugen Uhlmann, Glashuetten, DE;
Joachim Engels, Kronberg, DE;
Michaela Scherr, Oberursel, DE;
Arnold Ganser, Hannover, DE;
Assignee:
Hoechst Aktiengesellschaft, Frankfurt, am Main, DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07H / ;
U.S. Cl.
CPC ...
536 245 ; 435-6 ; 435375 ;
Abstract
Enzymatic RNA molecules have been designed that cleave mutant N-ras mRNA, preferably at a NUX cleavage site (N=any base, X=A, C or U). Preferred ribozymes have nucleotide sequences 5'-CCAACACCUGAUGAGCGUUAGCGAAACCUGCU-3' or 5'-UCCCAACCUGAUGAGCGUUAGCGAAACACCUG-3' (SEQ ID NOS:1 and 2), and derivatives thereof. The present invention also provides pharmaceuticals containing such molecules and the use of such molecules for the preparation of pharmaceuticals for the treatment of diseases involving abnormal cell growth and/or differentiation.