The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 2000
Filed:
Nov. 19, 1998
Derek Lowe, Scotch Plains, NJ (US);
Wei Chang, Livingston, NJ (US);
Joseph Kozlowski, Princeton, NJ (US);
Joel G Berger, Cedar Grove, NJ (US);
Robert McQuade, Scotch Plains, NJ (US);
Allen Barnett, Pine Brook, NJ (US);
Margaret Sherlock, Bloomfield, NJ (US);
Wing Tom, Cedar Grove, NJ (US);
Sundeep Dugar, Bridgewater, NJ (US);
Lian-Yong Chen, Edison, NJ (US);
John W Clader, Cranford, NJ (US);
Samuel Chackalamannil, East Brunswick, NJ (US);
Wang Yuguang, North Brunswick, NJ (US);
Stuart W McCombie, Caldwell, NJ (US);
Jayaram R Tagat, Westfield, NJ (US);
Susan F Vice, Mountainside, NJ (US);
Wayne Vaccaro, Yardley, PA (US);
Michael J Green, Skillman, NJ (US);
Margaret E Browne, Bloomfield, NJ (US);
Theodros Asberom, West Orange, NJ (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.21, R.sup.27, R.sup.28, X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.