The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 22, 2000
Filed:
Jul. 13, 1994
Tetsuro Kuga, Yamaguchi, JP;
Hiromasa Miyaji, Tokyo, JP;
Moriyuki Sato, Tokyo, JP;
Masami Okabe, Shizuoka, JP;
Makoto Morimoto, Shizuoka, JP;
Seiga Itoh, Kanagawa, JP;
Motoo Yamasaki, Tokyo, JP;
Yoshiharu Yokoo, Kanagawa, JP;
Kazuo Yamaguchi, Kanagawa, JP;
Hajime Yoshida, Kanagawa, JP;
Yoshinori Komatsu, Salt Lake City, UT (US);
Kyowa Hakko Kogyo Co., Ltd., , JP;
Abstract
Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.