The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2000
Filed:
Oct. 14, 1998
Applicant:
Inventors:
Sowmianarayanan Ramaswamy, Bridgewater, NJ (US);
Venkat G Reddy, Highland Park, NJ (US);
Yalin Luo, New Providence, NJ (US);
Assignee:
Chiragene, Inc., Warren, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; C07C / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
560 23 ; 560 27 ; 560 39 ; 560 42 ; 560 53 ; 564165 ; 564167 ;
Abstract
The present invention provides an efficient route to the C-13 side chain of the anti-cancer drug paclitaxel (TAXOL) and its analogs. The process includes the resolution of racemic erythro 2-hydroxy-3-amino-3-phenylpropionamide by diastereomeric crystallization and its conversion via various intermediates to the threo-ethylester and threo-methylester isomers.