The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2000
Filed:
May. 27, 1997
Applicant:
Inventors:
Paul F Jackson, Bel Air, MD (US);
Barbara S Slusher, Kingsville, MD (US);
Kevin L Tays, Elkridge, MD (US);
Keith M Maclin, Baltimore, MD (US);
Assignee:
Guilford Pharmaceuticals Inc., Baltimore, MD (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07F / ; C07F / ; A61K / ;
U.S. Cl.
CPC ...
514 75 ; 562-8 ; 562 24 ; 546 22 ; 546 21 ; 548412 ; 548413 ; 549-5 ; 549-6 ; 549216 ; 549218 ;
Abstract
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.