The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2000
Filed:
Nov. 17, 1998
Takashi Nakamura, Kawasaki, JP;
Tatsuya Nakayama, Kawasaki, JP;
Yosuke Koyama, Saga-ken, JP;
Keishi Shimazaki, Saga-ken, JP;
Harufumi Miwa, Kawasaki, JP;
Minoru Tsuruta, Kawasaki, JP;
Koji Tamura, Kawasaki, JP;
Osamu Tosaka, Saga-ken, JP;
Ajinomoto Co., Inc., Tokyo, JP;
Abstract
The present invention relates to a method for controlling carbon source concentration in the aerobic cultivation of a microorganism. The substrate carbon source remains at a low level in a cultivation vessel during the culture feeding in aerobic fed-batch, continuous or cell-recycling continuous cultures. This is accomplished by monitoring the increase in pH or dissolved oxygen content in the culture medium and adding the feed solution intermittently into a cultivation vessel at a calculated feed rate using a feed control device controlled by a computer. The present invention further relates to a process for producing L-lysine by fermentation having the advantages over the prior methods, those being improved productivity, higher concentrations of accumulated product, and increased yields of L-lysine.