The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 15, 2000
Filed:
Nov. 14, 1997
Applicant:
Inventors:
Roy Curtiss, III, St. Louis, MO (US);
Cheryl A Nickerson, Chesterfield, MO (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; A61K / ; A61K / ; C12N / ;
U.S. Cl.
CPC ...
4242001 ; 424 932 ; 435471 ; 4352523 ; 4352528 ; 435-4 ; 435 27 ; 435 29 ;
Abstract
Avirulent immunogenic Salmonella enterica serotype Typhi and methods therefor are disclosed. The Salmonella have an RpoS.sup.+ phenotype, an inactivating mutation in one or more genes which renders the microbe avirulent, and a recombinant gene capable of expressing a desired protein. The Salmonella are avirulent and have high immunogenicity so that they can be used in vaccines and as delivery vehicles for the desired antigen. Also disclosed are methods for preparing the Salmonella and vaccine delivery vehicles therefor.