The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 08, 2000
Filed:
Nov. 20, 1997
Applicant:
Inventors:
Darren Magda, Cupertino, CA (US);
Shaun P Crofts, Campbell, CA (US);
Meredith Wright, San Jose, CA (US);
Assignee:
Pharmacyclics, Inc., Sunnyvale, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H / ;
U.S. Cl.
CPC ...
536 231 ; 536 221 ; 536 253 ; 536 2531 ; 536 2532 ; 536 2534 ; 534 11 ; 534 13 ; 534 15 ; 534 16 ; 540149 ; 540465 ; 540472 ;
Abstract
Texaphyrin metal complex-oligonucleotide and -oligonucleotide analog conjugates are provided where the texaphyrin is bound to an internal linkage of the oligonucleotide or oligonucleotide analog, the conjugates having catalytic activity for the hydrolysis of ribonucleic acid. Further, conjugates demonstrating catalytic turnover are described, the conjugates being especially effective under conditions where the concentration of RNA target exceeds that of available conjugate.