The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2000
Filed:
Aug. 20, 1997
Applicant:
Inventor:
Gregg L Semenza, Towson, MD (US);
Assignee:
The Johns Hopkins University School of Medicine, Baltimore, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C12N / ;
U.S. Cl.
CPC ...
530350 ; 536 235 ;
Abstract
The purified and characterization of hypoxia-inducible factor 1 (HIF-1) is described. HIF-1 is composed of subunits HIF-1a and HIF-1.beta.. Purified HIF-1a polypeptide, its amino acid sequence and polynucleotide sequence are provided. A HIF-1.alpha. variant that dimerizes to HIF-1.beta. producing a nonfunctional HIF-1 complex is described. Methods for the prevention and treatment of hypoxia-related disorders are provided.