The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 01, 2000
Filed:
Mar. 21, 1997
Christina Carlsson, Sodertalje, SE;
Maria T Dulay, Stanford, CA (US);
Mats Jonsson, Gothenberg, SE;
Peter Nielson, Copenhagen, DK;
Bengt Norden, Gothenberg, SE;
Lap-Chee Tsui, Toronto, CA;
Richard Zare, Stanford, CA (US);
Julian Zielinski, Toronto, CA;
HSC, Reasearch and Development Limited Partnership, Toronto, CA;
The Board of Trustees of The Leland Stamford Junior University, Palo Alto, CA (US);
Abstract
A rapid and sensitive detection method capable of reliably distinguishing fragments identical to a defined sequence from fragments containing a single base pair mismatch relative to the defined sequence. The method employs a peptide analog antisense probe, such as a peptide nucleic acid (PNA) probe, which hybridizes with DNA to forms complexes having higher thermal stability, but greater sensitivity to base pair mismatches, than corresponding DNA/DNA complexes. The method may be used in a number of applications, including genetic screening and hybridization sequencing applications.