The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 18, 2000
Filed:
Sep. 11, 1998
Lorne M Golub, Smithtown, NY (US);
Christopher T Ritchlin, Canandaigua, NY (US);
Robert A Greenwald, Melville, NY (US);
Sally Haas-Smith, Penfield, NY (US);
Susan A Moak, Bayside, NY (US);
Hsi-Ming Lee, Setauket, NY (US);
The Research Foundation of State University of New York, Albany, NY (US);
University of Rochester, Rochester, NY (US);
Abstract
The invention is a method of enhancing endogenous interleukin-10 production in mammalian cells and tissues, which includes administering an effective amount of a tetracycline derivative. The method also includes enhancing interleukin-10 production by administering an effective amount of the tetracycline derivative to a mammal. Preferred tetracycline compounds are tetracycline compounds which have been modified to reduce or eliminate their antimicrobial activity. The method can be used to treat medical conditions in mammals characterized by excessive IL-1 and TNF .alpha. production.