The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 11, 2000
Filed:
Mar. 30, 1998
Applicant:
Inventors:
Chris Hugh Senanayake, Shrewsbury, MA (US);
Roger P Bakale, Shrewsbury, MA (US);
Qun Kevin Fang, Wellesley, MA (US);
Paul Timothy Grover, Marlborough, MA (US);
Donald L Heefner, Hudson, MA (US);
Richard F Rossi, Norton, MA (US);
Stephen Alan Wald, Sudbury, MA (US);
Assignee:
Sepracor Inc., Malborough, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C / ; C07D / ;
U.S. Cl.
CPC ...
560 58 ; 548217 ; 548498 ;
Abstract
Processes for preparing a single enantiomer of an .alpha.,.alpha.-disubstituted-.alpha.-hydroxy acetic acid, especially cyclohexylphenylglycolic acid (CHPGA), is disclosed. The processes employ cyclic 1,2-aminoalcohols as chiral auxiliaries by forming diastereomeric esters of aminoalcohols or diastereomeric amides of oxazolidines. ##STR1## Intermediates useful in the process are also disclosed.