The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 1999
Filed:
Jul. 09, 1997
Tomas Girbes Juan, Valladolid, ES;
Jose Miguel Ferreras Rodriguez, Valladolid, ES;
Rosario Iglesias Alvarez, Valladolid, ES;
Lucia Citores Gonzalez, Valladolid, ES;
Francisco Javier Arias Vallejo, Valladolid, ES;
Ma Angeles Rojo Rodriguez, Palencia, ES;
Raquel Munoz Martinez, Soria, ES;
Pilar Jimenez Lopez, Valladolid, ES;
Fernando Martinez De Benito, Valladolid, ES;
Universidad De Valladolid, Valladolid, ES;
Abstract
The invention discloses ribosome inactivating proteins (RIPs) with two chains, which arc not toxic in the extra-cellular environment, of plant origin, and capable of interacting with ribonucleic acid and causing the inhibition of the biosynthesis of proteins in cellular systems, said proteins being comprised of two chains A and B, chain A having a N-glucosidase activity of the ribosomal ribonucleic acid, and chain B having a lectine activity, both chains being joined by disulphide bridges. Among the proteins, Nigrine b isolated from bark of Sambucus nigra L., basic Nigrine l isolated from the leaves of Sambucus nigra L., Ebuline 1 isolated from leaves of Sambucus ebulus L. and Racenosine b isolated from the bark of Sambucus racemosa L. are mentioned. The proteins find application as inactivators of the rebonucleic acid and as inhibitors of the protein synthesis.