The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 28, 1999
Filed:
Apr. 10, 1996
Applicant:
Inventors:
Assignee:
Hoechst Marion Roussel Deutschland GmbH, Frankfurt am Main, DE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
435 697 ; 435 696 ; 435170 ; 435183 ; 435189 ; 435471 ; 43525233 ; 435849 ; 5303873 ; 4241341 ; 424801 ; 536 232 ; 536 234 ; 536 2353 ;
Abstract
The invention relates to the cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli. In particular, antibody fragment fusion molecules having an antibody moiety which is directed against tumors and an enzyme moiety which cleaves a nontoxic prodrug to give the toxic drug can be advantageously prepared in this way while retaining their respective functional properties.