The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 1999
Filed:
Feb. 22, 1996
National Science Council, Taipei, TW;
Abstract
This invention is a heterobifunctional artificial cornea or biomedical membrane and novel process for preparing the heterobifunctional artificial cornea. In this method, plasma induced graft polymerization is adopted to provide the surface property modification of polymer materials like silicone or polyurethane. At first, the frontal side of the material is grafted with polyacrylic acid or polymethacrylic acid and then bonded with collagen, or 2-hydroxyethylmethacrylate (HEMA) is grafted alone. A surface which increases the cell attachment and growth can be then developed. Another side of this membrane is grafted with acrylic acid or polymethacrylic acid and then different molecular weights of polyethylene oxide (PEO) is bonded thereto. 2-methacryloyl-oxyethyl phosphoryl chloride (2-MPC) is grafted to the membrane. The copolymer of the 2-methacryl-oyloxyethyl phosphoryl chloride and MPC-co-butyl methacrylate can be used in preparing a special surface which can inhibit the attachments of cells and protein molecules. Thus, a heterobi-functional biomedical membrane can be developed. In this work, the surface characterization of this membrane, in vitro study and animal in vivo study are also investigated. The obtained results exhibit a very good performance. Moreover, it demonstrates that the developed product has good transparency, hydrophilicity and high biocompatibility, thereby exhibiting the high potential in the application field of artificial cornea.