The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 21, 1999
Filed:
Apr. 25, 1996
Applicant:
Inventors:
Jacques Banchereau, Ecully, FR;
Christophe Caux, Lyons, FR;
Assignee:
Schering Corporation, Kenilworth, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ;
U.S. Cl.
CPC ...
435325 ; 435347 ; 435373 ; 435326 ;
Abstract
A method is provided for generating human dendritic cells in vitro by treating CD34.sup.+ cells with tumor necrosis factor-.alpha. and interleukin-3 or with GM-CSF. The invention also includes cellular compositions of dendritic cells produced by this method. Dendritic cells of the invention can be used widely as components in many diagnostic and therapeutic systems, including improved mixed lymphocyte reactions for assaying tissue rejection, adoptive immunotherapy of cancer, adoptive immunotherapy of HIV and other viral infections, and SCID-hu mice for human antibody production.