The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 14, 1999
Filed:
Mar. 31, 1997
Applicant:
Inventors:
Barbara D Boyan, San Antonio, TX (US);
Zvi Schwartz, Jerusalem, IL;
Assignee:
OsteoBiologics, Inc., San Antonio, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C12N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
424 937 ; 424423 ; 424426 ; 424548 ; 435177 ; 435180 ; 435325 ; 435366 ; 435375 ; 435377 ; 435384 ; 435395 ; 435396 ; 435405 ;
Abstract
A method for stimulating chondrocyte proliferation and inhibiting chondrocyte differentiation along the endochondral developmental pathway is provided comprising contacting condrocytes with an effective amount of Platelet-Derived Growth Factor (PDGF) such as PDGF-BB, PDGF-AA OR PDGF-AB in the substantial absence of growth factors which promote cell differentiation. This allows such cells to be multiplied in culture for loading onto a scaffolding material and implanting into a cartilage or bone wound.