Endodiagnostic method using differential thermal relaxation and ir

Abstract

Endodiagnostic methods utilize differential thermal relaxation and IR and visible imaging to differentiate between normal and abnormal interior body structures and tissue. With the use of a separate or integrated visible endoscope, an interior body site to be examined is visualized and then the area of interest is flooded with a cooling liquid. Upon contact with the area of interest, an immediate cooling of the flush site takes place, thus providing a temperature differential of approximately 25 degrees Fahrenheit of the cooled site compared to surrounding body-temperature tissue. As the area warms back to the surrounding tissue temperature, abnormal areas can be visualized because their temperature warms at a different rate compared to normal structure or tissue. As time progresses the contrast between normal and abnormal reaches a maximum and then declines as both relax back to body temperature. During the relaxation period infrared emissions within the range including 2 to 14 micrometers are visualized in the form of encoded images to permit differential analysis. This is done via endoscopic apparatus having separate or integrated IR and visible channels. The IR channel preferably comprises a refractive objective lens for forming a real image of interior structure of interest, a relay system consisting solely of refracting elements for transferring the real image to an intermediate image plane conjugate to the objective image plane, and a refracting coupling lens for forming a final image of the intermediate image in a detector plane for an IR detector sensitive in the range including 2 to 14 micrometers.