The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 1999
Filed:
Jan. 16, 1998
Applicant:
Inventors:
Yutaka Kawakami, Rockville, MD (US);
Steven A Rosenberg, Potomac, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; C07H / ; C12N / ;
U.S. Cl.
CPC ...
536 235 ; 4242771 ; 4241741 ; 4243201 ; 530300 ; 435 911 ; 435371 ; 435344 ; 435 693 ; 514 15 ; 514 16 ; 536 231 ;
Abstract
The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal afflicted with melanoma or metastata melanoma. This invention also provides immunogenic peptides derived from the MART-1 melanoma antigen and a second melanoma antigen designated gp100. The proteins and peptides provided can serve as an immunogen or vaccine to prevent or treat melanoma.