The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 30, 1999
Filed:
Nov. 07, 1997
Laszlo S Bajzar, Kingston, CA;
Michael E Nesheim, Kingston, CA;
William R Church, Winooski, VT (US);
University of Vermont, Burlington, VT (US);
Abstract
Methods and products for the treatment of a disorder characterized by the cleavage of a C-terminal lysine or arginine from an intact peptide are provided. In the methods of the invention a peptide that inhibits the activation of thrombin-activatable fibrinolysis inhibitor (TAFI) is administered in an effective amount and in a pharmaceutically acceptable carrier to a subject having a disorder characterized by the cleavage of a C-terminal lysine or arginine from an intact peptide. The compositions are pharmaceutical compositions of peptides that inhibit the activation of TAFI. Also provided is a monoclonal antibody that binds TAFI zymogen but that does not bind to active TAFI and inhibits the activation of TAFI.