The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 1999
Filed:
Aug. 14, 1995
Applicant:
Inventors:
Sabera Ruzdijic, Santa Ana, CA (US);
Zbigniew Pietrzkowski, Santa Ana, CA (US);
Dariusz Cieslak, Santa Ana, CA (US);
Assignee:
ICN Pharmaceuticals, Inc., Costa Mesa, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H / ; C07H / ;
U.S. Cl.
CPC ...
536 245 ; 536 231 ;
Abstract
Neoplastic cells which over-express CD44, including especially non-small cell lung cancer and melanoma cancer cells, are treated with antisense oligonucleotides to control CD44 expression. Test results show that the claimed oligonucleotides significantly decreases cell growth in a CD44 sequence specific manner of lung cancer or melanoma cells, or both, but are largely non-toxic to normal cells. Examples of dosing in a clinical setting are provided.