The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 1999
Filed:
Dec. 03, 1996
Applicant:
Inventors:
Ira Pastan, Potomac, MD (US);
Mark Willingham, Summerville, SC (US);
David Fitzgerald, Rockville, MD (US);
Ulrich Brinkmann, Kensington, MD (US);
Lee Pai, Silver Spring, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C07H / ;
U.S. Cl.
CPC ...
536 2353 ; 5303873 ; 435 691 ;
Abstract
This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for single chain Fv regions of the monoclonal antibody B3. The invention also provides for a method of improving the binding affinity of antibodies lacking a serine at position 95 of the V.sub.H region that involves mutating position 95 to a serine.