The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 1999
Filed:
May. 20, 1998
Applicant:
Inventors:
Michael D Bentley, Huntsville, AL (US);
J Milton Harris, Huntsville, AL (US);
Assignee:
Shearwater Polymers, Inc., Huntsville, AL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; C08L / ;
U.S. Cl.
CPC ...
525 542 ; 525 56 ; 525107 ; 525154 ;
Abstract
The present invention provides a method of coupling PEG or related polymers to a substance by reductive amination. An activated PEG having an aldehyde hydrate moiety is prepared and is conveniently used as an intermediate for coupling PEG to a variety of biomolecules by reductive amination. The method of making PEG-conjugated biomolecules in accordance with the present invention avoids the condensation and oxidation reactions that are inherent in the coupling methods employed heretofore in the prior art using PEG aldehyde. As a result, high purity of PEG-conjugates can be achieved.
Published as: